Open AccessMultiplex optical biosensors based on multi-pinhole interferometry
Author(s) -
Johannes Bläsi,
Martina Gerken
Publication year - 2021
Publication title -
biomedical optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.426991
Subject(s) - multiplex , leverage (statistics) , computer science , interferometry , biosensor , multiplexing , nanotechnology , optics , materials science , artificial intelligence , bioinformatics , telecommunications , physics , biology
The application of new sensor technologies for frequent biomarker monitoring in combination with the leverage of artificial intelligence has great potential to improve the design and safety of health care. With current research efforts, the screening of tens of biomarkers at the point of care and immediate adjustment of therapy is coming within reach. Here we introduce an optical multiplexing approach based on multi-pinhole interference providing inherent differential referencing between a multitude of measurement fields on a surface. A theoretical study of an 11-plex and a 54-plex design is complemented with the experimental demonstration of the technique for a 3-field refractive index measurements and detection of human α -thrombin.