Centimeter-scale wide-field-of-view laser-scanning photoacoustic microscopy for subcutaneous microvasculature in vivo | Zendy

Tangyun Liao | Zendy; Yuan Liu | Zendy; JimWei Wu | Zendy; Lijun Deng | Zendy; Yu Deng | Zendy; Lvming Zeng | Zendy; Xuanrong Ji | Zendy

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Centimeter-scale wide-field-of-view laser-scanning photoacoustic microscopy for subcutaneous microvasculature in vivo

Author(s) -

Tangyun Liao,

Yuan Liu,

JimWei Wu,

Lijun Deng,

Yu Deng,

Lvming Zeng,

Xuanrong Ji

Publication year - 2021

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.426366

Subject(s) - optics , microscopy , materials science , preclinical imaging , laser , biomedical engineering , in vivo , resolution (logic) , laser scanning , centimeter , image resolution , medicine , physics , computer science , biology , surgery , microbiology and biotechnology , artificial intelligence

We developed a simple and compact laser-scanning photoacoustic microscopy (PAM) for imaging large areas of subcutaneous microvasculature in vivo. The reflection-mode PAM not only retains the advantage of high scanning speed for optical scanning, but also offers an imaging field-of-view (FOV) up to 20 × 20 mm 2 , which is the largest FOV available in laser-scanning models so far. The lateral resolution of the PAM system was measured to be 17.5 µm. Image experiments on subcutaneous microvasculature in in vivo mouse ears and abdomen demonstrate the system's potential for fast and high-resolution imaging for injuries and diseases of large tissues and organs.

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