Open AccessPhotoacoustic computed tomography for functional human brain imaging [Invited]
Author(s) -
Shuai Na,
Lihong V. Wang
Publication year - 2021
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.423707
Subject(s) - diffuse optical imaging , magnetic resonance imaging , preclinical imaging , photoacoustic imaging in biomedicine , photoacoustic tomography , molecular imaging , functional imaging , neuroimaging , optical imaging , modality (human–computer interaction) , tomography , computer science , functional magnetic resonance imaging , optical tomography , human brain , image resolution , biomedical engineering , optics , medicine , artificial intelligence , in vivo , physics , radiology , microbiology and biotechnology , biology , psychiatry
The successes of magnetic resonance imaging and modern optical imaging of human brain function have stimulated the development of complementary modalities that offer molecular specificity, fine spatiotemporal resolution, and sufficient penetration simultaneously. By virtue of its rich optical contrast, acoustic resolution, and imaging depth far beyond the optical transport mean free path (∼1 mm in biological tissues), photoacoustic computed tomography (PACT) offers a promising complementary modality. In this article, PACT for functional human brain imaging is reviewed in its hardware, reconstruction algorithms, in vivo demonstration, and potential roadmap.