Open AccessDifferentiation of breast tissue types for surgical margin assessment using machine learning and polarization-sensitive optical coherence tomography
Author(s) -
Dan Zhu,
Jianfeng Wang,
Marina Marjanović,
Eric J. Chaney,
Kimberly A. Cradock,
Anna M. Higham,
Zheng G Liu,
Zhishan Gao,
Stephen A. Boppart
Publication year - 2021
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.423026
Subject(s) - optical coherence tomography , breast cancer , histology , computer science , biomedical engineering , artificial intelligence , nuclear medicine , medicine , pathology , radiology , cancer
We report an automated differentiation model for classifying malignant tumor, fibro-adipose, and stroma in human breast tissues based on polarization-sensitive optical coherence tomography (PS-OCT). A total of 720 PS-OCT images from 72 sites of 41 patients with H&E histology-confirmed diagnoses as the gold standard were employed in this study. The differentiation model is trained by the features extracted from both one standard OCT-based metric (i.e., intensity) and four PS-OCT-based metrics (i.e., phase difference between two channels ( PD ), phase retardation ( PR ), local phase retardation ( LPR ), and degree of polarization uniformity ( DOPU )). Further optimized by forward searching and validated by leave-one-site-out-cross-validation (LOSOCV) method, the best feature subset was acquired with the highest overall accuracy of 93.5% for the model. Furthermore, to show the superiority of our differentiation model based on PS-OCT images over standard OCT images, the best model trained by intensity-only features (usually obtained by standard OCT systems) was also obtained with an overall accuracy of 82.9%, demonstrating the significance of the polarization information in breast tissue differentiation. The high performance of our differentiation model suggests the potential of using PS-OCT for intraoperative human breast tissue differentiation during the surgical resection of breast cancer.