Open AccessPhotoacoustic imaging of the spatial distribution of oxygen saturation in an ischemia-reperfusion model in humans
Author(s) -
Aboma Merdasa,
Josefine Bunke,
Magdaleumovska,
John Albinsson,
Tobias Erlöv,
Magnus Cinthio,
Nina Reistad,
Rafi Sheikh,
Malin Malmsjö
Publication year - 2021
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.418397
Subject(s) - photoacoustic imaging in biomedicine , occlusion , hyperspectral imaging , ischemia , biomedical engineering , photoacoustic spectroscopy , preclinical imaging , oxygen saturation , optical imaging , ultrasound , in vivo , medicine , materials science , oxygen , radiology , optics , chemistry , computer science , artificial intelligence , biology , physics , microbiology and biotechnology , organic chemistry
Photoacoustic imaging (PAI) is a novel hybrid imaging technique that combines the advantages of optical and ultrasound imaging to produce hyperspectral images of the tissue. The feasibility of measuring oxygen saturation (sO 2 ) with PAI has been demonstrated pre-clinically, but has limited use in humans under conditions of ischemia and reperfusion. As an important step towards making PAI clinically available, we present a study in which PAI was used to estimate the spatial distribution of sO 2 in vivo during and after occlusion of the finger of eight healthy volunteers. The results were compared with a commercial oxygen saturation monitor based on diffuse reflectance spectroscopy. We here describe the capability of PAI to provide spatially resolved picture of the evolution of sO 2 during ischemia following vascular occlusion of a finger, demonstrating the clinical viability of PAI as a non-invasive diagnostic tool for diseases indicated by impaired microvascularization.