Open AccessAttenuation coefficient estimation in Fourier-domain OCT of multi-layered phantoms
Author(s) -
Babak Ghafaryasl,
Koenraad A. Vermeer,
Jeroen Kalkman,
Tom Callewaert,
Johannes F. de Boer,
Lucas J. van Vliet
Publication year - 2021
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.415079
Subject(s) - attenuation , attenuation coefficient , imaging phantom , optics , signal (programming language) , rayleigh scattering , materials science , fourier transform , scattering , computer science , physics , mathematics , mathematical analysis , programming language
Optical properties, such as the attenuation coefficients of multi-layer tissue samples, could be used as a biomarker for diagnosis and disease progression in clinical practice. In this paper, we present a method to estimate the attenuation coefficients in a multi-layer sample by fitting a single scattering model for the OCT signal to the recorded OCT signal. In addition, we employ numerical simulations to obtain the theoretically achievable precision and accuracy of the estimated parameters under various experimental conditions. Finally, the method is applied to two sets of measurements obtained from a multi-layer phantom by two experimental OCT systems: one with a large and one with a small Rayleigh length. Numerical and experimental results show an accurate estimation of the attenuation coefficients when using multiple B-scans.