Open AccessIn vivo test-driven upgrade of a time domain multi-wavelength optical mammograph
Author(s) -
Giulia Maffeis,
Edoardo Ferocino,
Alberto Dalla Mora,
Antonio Pifferi,
Rinaldo Cubeddu,
Paola Taroni
Publication year - 2021
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.412210
Subject(s) - upgrade , computer science , in vivo , repeatability , medical physics , consistency (knowledge bases) , time domain , biomedical engineering , optics , medicine , artificial intelligence , computer vision , mathematics , biology , physics , statistics , microbiology and biotechnology , operating system
A recent upgrade of the time domain multi-wavelength optical mammograph developed by Politecnico di Milano achieved good performance in laboratory tests [Biomed. Opt. Express9, 755 (2018).10.1364/BOE.9.000755]. However, it proved unsatisfactory when in vivo measurements were finally performed. That led to a further upgrade, including the replacement of the time-to-digital converter with a new model, and the related set-up changes. The new instrument version offers improved laboratory performance (as assessed through established protocols: BIP and MEDPHOT) and good in vivo performance (extension of the scanned breast area, repeatability, consistency of estimated tissue composition with physiology). Besides introducing the new set-up and detailing its laboratory and in vivo performance, we highlight the importance of systematic in vivo testing before entering clinical trials.