Open AccessTowards ultrahigh resolution OCT based endoscopical pituitary gland and adenoma screening: a performance parameter evaluation
Author(s) -
Fabian Placzek,
Alexander Micko,
Ryan Sentosa,
Roger Fonollà,
Michael Winklehner,
Arthur Hosmann,
Marco Andreana,
Romana Höftberger,
Wolfgang Drexler,
Rainer A. Leitgeb,
Stefan Wolfsberger,
Angelika Unterhuber
Publication year - 2020
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.409987
Subject(s) - optical coherence tomography , endoscope , in vivo , ex vivo , adenoma , pathology , pituitary adenoma , resolution (logic) , high resolution , pituitary gland , preclinical imaging , biomedical engineering , medicine , radiology , biology , computer science , artificial intelligence , remote sensing , microbiology and biotechnology , geology , hormone
Ultrahigh resolution optical coherence tomography (UHR-OCT) for differentiating pituitary gland versus adenoma tissue has been investigated for the first time, indicating more than 80% accuracy. For biomarker identification, OCT images of paraffin embedded tissue are correlated to histopathological slices. The identified biomarkers are verified on fresh biopsies. Additionally, an approach, based on resolution modified UHR-OCT ex vivo data, investigating optical performance parameters for the realization in an in vivo endoscope is presented and evaluated. The identified morphological features-cell groups with reticulin framework-detectable with UHR-OCT showcase a promising differentiation ability, encouraging endoscopic OCT probe development for in vivo application.