Towards ultrahigh resolution OCT based endoscopical pituitary gland and adenoma screening: a performance parameter evaluation | Zendy

Fabian Placzek | Zendy; Alexander Micko | Zendy; Ryan Sentosa | Zendy; Roger Fonollà | Zendy; Michael Winklehner | Zendy; Arthur Hosmann | Zendy; Marco Andreana | Zendy; Romana Höftberger | Zendy; Wolfgang Drexler | Zendy; Rainer A. Leitgeb | Zendy; Stefan Wolfsberger | Zendy; Angelika Unterhuber | Zendy

Open Access

Towards ultrahigh resolution OCT based endoscopical pituitary gland and adenoma screening: a performance parameter evaluation

Author(s) -

Fabian Placzek,

Alexander Micko,

Ryan Sentosa,

Roger Fonollà,

Michael Winklehner,

Arthur Hosmann,

Marco Andreana,

Romana Höftberger,

Wolfgang Drexler,

Rainer A. Leitgeb,

Stefan Wolfsberger,

Angelika Unterhuber

Publication year - 2020

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.409987

Subject(s) - adenoma , resolution (logic) , pituitary gland , pituitary adenoma , optics , medical physics , computer science , pathology , medicine , physics , artificial intelligence , hormone

Ultrahigh resolution optical coherence tomography (UHR-OCT) for differentiating pituitary gland versus adenoma tissue has been investigated for the first time, indicating more than 80% accuracy. For biomarker identification, OCT images of paraffin embedded tissue are correlated to histopathological slices. The identified biomarkers are verified on fresh biopsies. Additionally, an approach, based on resolution modified UHR-OCT ex vivo data, investigating optical performance parameters for the realization in an in vivo endoscope is presented and evaluated. The identified morphological features-cell groups with reticulin framework-detectable with UHR-OCT showcase a promising differentiation ability, encouraging endoscopic OCT probe development for in vivo application.

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