Open AccessPorcine skin damage threshold from mid-infrared optical parametric oscillator radiation at 3.743 µm
Author(s) -
Lei Jiao,
Chao Wang,
Kaizeng Zhang,
Jiarui Wang,
Zaifu Yang
Publication year - 2020
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.409387
Subject(s) - optics , wavelength , laser , materials science , irradiance , radiation , laser safety , optical parametric oscillator , infrared , optoelectronics , physics
There is increasing use of mid-infrared optical parametric oscillator radiation operating in the wavelength range of 3-5 µm. To expand existing damage data for skin exposure to lasers in this wavelength region, the in-vivo damage threshold at the wavelength of 3.743 µm was determined in a Guizhou miniature pig model for an exposure duration of 1.0 s. The irradiance of the laser spot was nearly Gaussian-distributed and the 1/e 2 beam diameter on the animal skin surface was fixed at 0.94 and 0.88 cm along horizontal and vertical directions. Damage lesion determinations were performed at 1- and 24-hour post-exposure. The probit analysis was employed to establish the ED 50 values. The ED 50 expressed in peak radiant exposure for the Gaussian spot was 4.04 J/cm 2 at the 24-hour post-exposure. Sufficient margin existed between the damage threshold and MPE from the current laser safety standard. The obtained data may contribute to the knowledge base for refinement of laser safety standard in the wavelength range of 2.6-1000 µm.