Rapid and label-free urine test based on surface-enhanced Raman spectroscopy for the non-invasive detection of colorectal cancer at different stages | Zendy

Jinyong Lin | Zendy; Zongwei Huang | Zendy; Xueliang Lin | Zendy; Qiong Wu | Zendy; Kerun Quan | Zendy; Yanming Cheng | Zendy; Mingzhi Zheng | Zendy; Jiaying Xu | Zendy; Yitao Dai | Zendy; Hejin Qiu | Zendy; Duo Lin | Zendy; Shangyuan Feng | Zendy

Open Access

Rapid and label-free urine test based on surface-enhanced Raman spectroscopy for the non-invasive detection of colorectal cancer at different stages

Author(s) -

Jinyong Lin,

Zongwei Huang,

Xueliang Lin,

Qiong Wu,

Kerun Quan,

Yanming Cheng,

Mingzhi Zheng,

Jiaying Xu,

Yitao Dai,

Hejin Qiu,

Duo Lin,

Shangyuan Feng

Publication year - 2020

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.406097

Subject(s) - urine , colorectal cancer , surface enhanced raman spectroscopy , cancer detection , medicine , linear discriminant analysis , raman spectroscopy , cancer , pathology , raman scattering , computer science , optics , artificial intelligence , physics

The concept of being able to urinate in a cup and screen for colorectal cancer (CRC) is fascinating to the public at large. Here, a simple and label-free urine test based on surface-enhanced Raman spectroscopy (SERS) was employed for CRC detection. Significant spectral differences among normal, stages I-II, and stages III-IV CRC urines were observed. Using discriminant function analysis, the diagnostic sensitivities of 95.8%, 80.9%, and 84.3% for classification of normal, stages I-II, and stages III-IV CRC were achieved in training model, indicating the great promise of urine SERS as a rapid, convenient and noninvasive method for CRC staging detection.

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