Open AccessRapid and label-free urine test based on surface-enhanced Raman spectroscopy for the non-invasive detection of colorectal cancer at different stages
Author(s) -
Jinyong Lin,
ZeNing Huang,
Xueliang Lin,
Qiong Wu,
Kerun Quan,
Yanming Cheng,
Mingfeng Zheng,
JiaYing Xu,
Yitao Dai,
Hejin Qiu,
Duo Lin,
Shouhua Feng
Publication year - 2020
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.406097
Subject(s) - urine , colorectal cancer , surface enhanced raman spectroscopy , cancer detection , linear discriminant analysis , raman spectroscopy , medicine , cancer , pathology , raman scattering , computer science , optics , artificial intelligence , physics
The concept of being able to urinate in a cup and screen for colorectal cancer (CRC) is fascinating to the public at large. Here, a simple and label-free urine test based on surface-enhanced Raman spectroscopy (SERS) was employed for CRC detection. Significant spectral differences among normal, stages I-II, and stages III-IV CRC urines were observed. Using discriminant function analysis, the diagnostic sensitivities of 95.8%, 80.9%, and 84.3% for classification of normal, stages I-II, and stages III-IV CRC were achieved in training model, indicating the great promise of urine SERS as a rapid, convenient and noninvasive method for CRC staging detection.