Detection of singlet oxygen luminescence for experimental corneal rose bengal photodynamic antimicrobial therapy | Zendy

Jeffrey Peterson | Zendy; Esdras Arrieta | Zendy; Marco Ruggeri | Zendy; Juan Silgado | Zendy; Keenan J. Mintz | Zendy; Ernesto H. Weisson | Zendy; Roger M. Leblanc | Zendy; Irene E. Kochevar | Zendy; Fabrice Manns | Zendy; Jean–Marie Parel | Zendy

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Detection of singlet oxygen luminescence for experimental corneal rose bengal photodynamic antimicrobial therapy

Author(s) -

Jeffrey Peterson,

Esdras Arrieta,

Marco Ruggeri,

Juan Silgado,

Keenan J. Mintz,

Ernesto H. Weisson,

Roger M. Leblanc,

Irene E. Kochevar,

Fabrice Manns,

Jean–Marie Parel

Publication year - 2020

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.405601

Subject(s) - rose bengal , photodynamic therapy , singlet oxygen , luminescence , antimicrobial , photosensitizer , rose (mathematics) , optics , medicine , materials science , chemistry , oxygen , optoelectronics , photochemistry , biology , microbiology and biotechnology , physics , organic chemistry , horticulture

Rose bengal photodynamic antimicrobial therapy (RB-PDAT) treats corneal infection by activating rose bengal (RB) with green light to produce singlet oxygen ( 1 O 2 ). Singlet oxygen dosimetry can help optimize treatment parameters. We present a 1 O 2 dosimeter for detection of 1 O 2 generated during experimental RB-PDAT. The system uses a 520 nm laser and an InGaAs photoreceiver with bandpass filters to detect 1 O 2 luminescence during irradiation. The system was validated in RB solutions and ex vivo in human donor eyes. The results demonstrate the feasibility of 1 O 2 dosimetry in an experimental model of RB-PDAT in the cornea.

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