Open AccessEffect of optical energy modulation on the thermal response of biological tissue: computational and experimental validations
Author(s) -
Vân Nam Tran,
Van Gia Truong,
Yong Wook Lee,
Hyun Wook Kang
Publication year - 2020
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.404827
Subject(s) - materials science , diffuser (optics) , modulation (music) , biomedical engineering , optics , coagulation , thermal , medicine , light source , acoustics , physics , psychiatry , meteorology
This study develops an energy modulation technique to attain a constant interstitial tissue temperature and to induce the predetermined thermal coagulation without carbonization in tissue. An optical diffuser was employed to deliver 1064 nm light to the biological tissue. The combined mode maintained the interstitial temperature at 70 °C for longer durations compared to the continuous wave mode. Coagulation volumes increased linearly with the time and met the predetermined treatment volume range (0.32-0.52 cm 3 ) after the combined treatment for 100 s. The combined modulation can be a feasible modality to induce the predetermined extent of thermal coagulation for treating papillary thyroid microcarcinoma.