Open AccessSpace-enhanced time-domain diffuse optics for determination of tissue optical properties in two-layered structures
Author(s) -
Ying-Hsi Lin,
Heidrun Wabnitz,
Thomas Gladytz,
Aleh Sudakou,
Rainer Macdonald,
Dirk Grosenick
Publication year - 2020
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.402181
Subject(s) - optics , monte carlo method , absorption (acoustics) , scattering , attenuation coefficient , imaging phantom , materials science , time domain , domain (mathematical analysis) , computational physics , physics , computer science , mathematics , mathematical analysis , statistics , computer vision
A novel methodology for solving the inverse problem of diffuse optics for two-layered structures is proposed to retrieve the absolute quantities of optical absorption and reduced scattering coefficients of the layers simultaneously. A liquid phantom with various optical absorption properties in the deep layer is prepared and experimentally investigated using the space-enhanced time-domain method. Monte-Carlo simulations are applied to analyze the different measurements in time domain, space domain, and by the new methodology. The deviations of retrieved values from nominal values of both layers' optical properties are simultaneously reduced to a very low extent compared to the single-domain methods. The reliability and uncertainty of the retrieval performance are also considerably improved by the new methodology. It is observed in time-domain analyses that for the deep layer the retrieval of absorption coefficient is almost not affected by the scattering properties and this kind of "deep scattering neutrality" is investigated and overcome as well.