Open AccessColon phantoms with cancer lesions for endoscopic characterization with optical coherence tomography
Author(s) -
Natalia Zulina,
Oscar Caravaca,
Guiqiu Liao,
Sara Gravelyn,
Morgane Schmitt,
Keshia Badu,
Lucile Héroin,
Michalina J. Gora
Publication year - 2021
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.402081
Subject(s) - optical coherence tomography , imaging phantom , medical imaging , preclinical imaging , optical imaging , diffuse optical imaging , medicine , tomography , endoscopy , radiology , pathology , medical physics , biomedical engineering , optics , in vivo , biology , physics , microbiology and biotechnology
Optical coherence tomography (OCT) is a growing imaging technique for real-time early diagnosis of digestive system diseases. As with other well-established medical imaging modalities, OCT requires validated imaging performance and standardized test methods for performance assessment. A major limitation in the development and testing of new imaging technologies is the lack of models for simultaneous clinical procedure emulation and characterization of healthy and diseased tissues. Currently, the former can be tested in large animal models and the latter can be tested in small animal disease models or excised human biopsy samples. In this study, a 23 cm by 23 cm optical phantom was developed to mimic the thickness and near-infrared optical properties of each anatomical layer of a human colon, as well as the surface topography of colorectal polyps and visual appearance compatible with white light endoscopy.