Open AccessMulti-speckle diffuse correlation spectroscopy to measure cerebral blood flow
Author(s) -
Krishna P. Murali,
Hari M. Varma
Publication year - 2020
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.401702
Subject(s) - speckle pattern , speckle imaging , measure (data warehouse) , optics , blood flow , spectroscopy , cerebral blood flow , correlation , frame rate , diffuse optical imaging , biomedical engineering , computer science , physics , medicine , mathematics , tomography , geometry , quantum mechanics , database
We present a multi-speckle diffuse correlation spectroscopy (DCS) system for measuring cerebral blood flow in the healthy adult human brain. In contrast to the need for a high frame rate camera to measure the multi-speckle intensity auto-correlation, we employ a low frame rate camera to measure the auto-correlation using the recently introduced multi-step volterra integral method (MVIM). The results are validated by comparison against the blood flow measured using standard DCS system.