Multi-speckle diffuse correlation spectroscopy to measure cerebral blood flow | Zendy

Murali Krishnamoorthy | Zendy; Hari M. Varma | Zendy

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Multi-speckle diffuse correlation spectroscopy to measure cerebral blood flow

Author(s) -

Murali Krishnamoorthy,

Hari M. Varma

Publication year - 2020

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.401702

Subject(s) - speckle pattern , speckle imaging , measure (data warehouse) , cerebral blood flow , blood flow , optics , correlation , frame rate , spectroscopy , diffuse optical imaging , intensity (physics) , computer science , biomedical engineering , medicine , physics , mathematics , geometry , quantum mechanics , database , tomography

We present a multi-speckle diffuse correlation spectroscopy (DCS) system for measuring cerebral blood flow in the healthy adult human brain. In contrast to the need for a high frame rate camera to measure the multi-speckle intensity auto-correlation, we employ a low frame rate camera to measure the auto-correlation using the recently introduced multi-step volterra integral method (MVIM). The results are validated by comparison against the blood flow measured using standard DCS system.

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