Open AccessTowards detection of brain injury using multimodal non-invasive neuromonitoring in adults undergoing extracorporeal membrane oxygenation
Author(s) -
Irfaan A. Dar,
Ilyas Khan,
Ross K. Maddox,
Olga Selioutski,
Kelly L. Donohue,
Mark Marinescu,
Sunil Prasad,
Nadim H. Quazi,
Jack S. Donlon,
Emily Loose,
Gabriel Ramirez,
Jingxuan Ren,
Joseph B. Majeski,
Kenneth Abramson,
Turgut Durdurán,
David R. Busch,
Regine Choe
Publication year - 2020
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.401641
Subject(s) - extracorporeal membrane oxygenation , medicine , transcranial doppler , cardiopulmonary bypass , electroencephalography , cerebral autoregulation , oxygenation , intensive care medicine , anesthesia , autoregulation , cardiology , blood pressure , psychiatry
Extracorporeal membrane oxygenation (ECMO) is a form of cardiopulmonary bypass that provides life-saving support to critically ill patients whose illness is progressing despite maximal conventional support. Use in adults is expanding, however neurological injuries are common. Currently, the existing brain imaging tools are a snapshot in time and require high-risk patient transport. Here we assess the feasibility of measuring diffuse correlation spectroscopy, transcranial Doppler ultrasound, electroencephalography, and auditory brainstem responses at the bedside, and developing a cerebral autoregulation metric. We report preliminary results from two patients, demonstrating feasibility and laying the foundation for future studies monitoring neurological health during ECMO.