Open AccessHER2 biosensing through SPR-envelope tracking in plasmonic optical fiber gratings
Author(s) -
Maxime Lobry,
Médéric Loyez,
Karima Chah,
Eman Hassan,
Erik Goormaghtigh,
Maria C. DeRosa,
Ruddy Wattiez,
Christophe Caucheteur
Publication year - 2020
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.401200
Subject(s) - biosensor , cladding mode , materials science , optics , fiber bragg grating , plasmon , cladding (metalworking) , surface plasmon resonance , optoelectronics , robustness (evolution) , optical fiber , computer science , fiber optic sensor , nanotechnology , wavelength , nanoparticle , physics , chemistry , polarization maintaining optical fiber , metallurgy , gene , biochemistry
In the biomedical detection context, plasmonic tilted fiber Bragg gratings (TFBGs) have been demonstrated to be a very accurate and sensitive sensing tool, especially well-adapted for biochemical detection. In this work, we have developed an aptasensor following a triple strategy to improve the overall sensing performances and robustness. Single polarization fiber (SPF) is used as biosensor substrate while the demodulation is based on tracking a peculiar feature of the lower envelope of the cladding mode resonances spectrum. This method is highly sensitive and yields wavelength shifts several tens of times higher than the ones reported so far based on the tracking of individual modes of the spectrum. An amplification of the response is further performed through a sandwich assay by the use of specific antibodies. These improvements have been achieved on a biosensor developed for the detection of the HER2 ( Human Epidermal Growth Factor Receptor-2 ) protein, a relevant breast cancer biomarker. These advanced developments can be very interesting for point-of-care biomedical measurements in a convenient practical way.