Open AccessCharacterizing human pancreatic cancer precursor using quantitative tissue optical spectroscopy
Author(s) -
Seung Yup Lee,
William R. Lloyd,
Mudit Chandra,
Robert H. Wilson,
Barbara J. McKenna,
Diane M. Simeone,
James M. Scheiman,
Mary Ann Mycek
Publication year - 2013
Publication title -
biomedical optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.4.002828
Subject(s) - pancreatic cancer , intraductal papillary mucinous neoplasm , spectroscopy , pathology , pancreas , fluorescence spectroscopy , fluorescence , cancer , materials science , chemistry , optics , medicine , biochemistry , physics , quantum mechanics
In a pilot study, multimodal optical spectroscopy coupled with quantitative tissue-optics models distinguished intraductal papillary mucinous neoplasm (IPMN), a common precursor to pancreatic cancer, from normal tissues in freshly excised human pancreas. A photon-tissue interaction (PTI) model extracted parameters associated with cellular nuclear size and refractive index (from reflectance spectra) and extracellular collagen content (from fluorescence spectra). The results suggest that tissue optical spectroscopy has the potential to characterize pre-cancerous neoplasms in human pancreatic tissues.