Open AccessNon-contact in vivo diffuse optical imaging using a time-gated scanning system
Author(s) -
Mikhail Mazurenka,
Laura Di Sieno,
Gianluca Boso,
Davide Contini,
Antonio Pifferi,
Alberto Dalla Mora,
Alberto Tosi,
Heidrun Wabnitz,
Rainer Macdonald
Publication year - 2013
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.4.002257
Subject(s) - diffuse optical imaging , functional near infrared spectroscopy , in vivo , optics , preclinical imaging , biomedical engineering , materials science , detector , optical imaging , nuclear magnetic resonance , physics , medicine , tomography , neuroscience , cognition , biology , microbiology and biotechnology , prefrontal cortex
We report on the design and first in vivo tests of a novel non-contact scanning imaging system for time-domain near-infrared spectroscopy. Our system is based on a null source-detector separation approach and utilizes polarization-selective detection and a fast-gated single-photon avalanche diode to record late photons only. The in-vivo tests included the recording of hemodynamics during arm occlusion and two brain activation tasks. Localized and non-localized changes in oxy- and deoxyhemoglobin concentration were detected for motor and cognitive tasks, respectively. The tests demonstrate the feasibility of non-contact imaging of absorption changes in deeper tissues.