Open AccessIn vivo vibrometry inside the apex of the mouse cochlea using spectral domain optical coherence tomography
Author(s) -
Simon S. Gao,
Patrick D. Raphael,
Rosalie H. Wang,
Jesung Park,
Anping Xia,
Brian E. Applegate,
John S. Oghalai
Publication year - 2013
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.4.000230
Subject(s) - cochlea , optical coherence tomography , inner ear , physics , optics , acoustics , anatomy , biology
Sound transduction within the auditory portion of the inner ear,the cochlea, is a complex nonlinear process. The study of cochlearmechanics in large rodents has provided important insights into cochlearfunction. However, technological and experimental limitations haverestricted studies in mice due to their smaller cochlea. These challenges areimportant to overcome because of the wide variety of transgenic mousestrains with hearing loss mutations that are available for study. Toaccomplish this goal, we used spectral domain optical coherencetomography to visualize and measure sound-induced vibrations ofintracochlear tissues. We present, to our knowledge, the first vibrationmeasurements from the apex of an unopened mouse cochlea