Open AccessBidirectional optical neuromodulation using capacitive charge-transfer
Author(s) -
Rustamzhon Melikov,
Shashi Bhushan Srivastava,
Onuralp Karatum,
Itir Bakis DogruYuksel,
Ugur Meric Dikbas,
İbrahim Halil Kavaklı,
Sedat Nizamoğlu
Publication year - 2020
Publication title -
biomedical optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.399755
Subject(s) - capacitive sensing , capacitance , capacitor , materials science , optoelectronics , neuromodulation , light intensity , waveform , hyperpolarization (physics) , computer science , biomedical engineering , electronic engineering , voltage , neuroscience , electrical engineering , optics , physics , engineering , electrode , nuclear magnetic resonance , quantum mechanics , stimulation , nuclear magnetic resonance spectroscopy , biology , operating system
Artificial control of neural activity allows for understanding complex neural networks and improving therapy of neurological disorders. Here, we demonstrate that utilization of photovoltaic biointerfaces combined with light waveform shaping can generate safe capacitive currents for bidirectional modulation of neurons. The differential photoresponse of the biointerface due to double layer capacitance facilitates the direction control of capacitive currents depending on the slope of light intensity. Moreover, the strength of capacitive currents is controlled by changing the rise and fall time slope of light intensity. This approach allows for high-level control of the hyperpolarization and depolarization of membrane potential at single-cell level. Our results pave the way toward advanced bioelectronic functionalities for wireless and safe control of neural activity.