Functional optical coherence tomography enables in vivo optoretinography of photoreceptor dysfunction due to retinal degeneration | Zendy

Tae-Hoon Kim | Zendy; Benquan Wang | Zendy; Yiming Lu | Zendy; Taeyoon Son | Zendy; Xincheng Yao | Zendy

Open Access

Functional optical coherence tomography enables in vivo optoretinography of photoreceptor dysfunction due to retinal degeneration

Author(s) -

Tae-Hoon Kim,

Benquan Wang,

Yiming Lu,

Taeyoon Son,

Xincheng Yao

Publication year - 2020

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.399334

Subject(s) - visual phototransduction , optical coherence tomography , retinal , retinal degeneration , retina , electroretinography , retinal regeneration , in vivo , optics , ophthalmology , biology , medicine , neuroscience , physics , microbiology and biotechnology

Stimulus-evoked intrinsic optical signal (IOS), which occurs almost immediately after the onset of retinal stimulus has been observed in retinal photoreceptors, promises to be a unique biomarker for objective optoretinography (ORG) of photoreceptor function. We report here the first-time in vivo ORG detection of photoreceptor dysfunction due to retinal degeneration. A custom-designed optical coherence tomography (OCT) was employed for longitudinal ORG monitoring of photoreceptor-IOS distortions in retinal degeneration mice. Depth-resolved OCT analysis confirmed the outer segment (OS) as the physical source of the photoreceptor-IOS. Comparative ERG measurement verified the phototransduction activation as the physiological correlator of the photoreceptor-IOS. Histological examination revealed disorganized OS discs, i.e. the pathological origin of the photoreceptor-IOS distortion.

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