Ge on Si waveguide mid-infrared absorption spectroscopy of proteins and their aggregates | Zendy

Vinita Mittal | Zendy; George Devitt | Zendy; Miloš Nedeljković | Zendy; Lewis G. Carpenter | Zendy; Harold M. H. Chong | Zendy; James S. Wilkinson | Zendy; Sumeet Mahajan | Zendy; Goran Z. Mashanovich | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Ge on Si waveguide mid-infrared absorption spectroscopy of proteins and their aggregates

Author(s) -

Vinita Mittal,

George Devitt,

Miloš Nedeljković,

Lewis G. Carpenter,

Harold M. H. Chong,

James S. Wilkinson,

Sumeet Mahajan,

Goran Z. Mashanovich

Publication year - 2020

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.398013

Subject(s) - infrared , infrared spectroscopy , absorption (acoustics) , spectroscopy , materials science , optics , absorption spectroscopy , waveguide , optoelectronics , chemistry , physics , organic chemistry , quantum mechanics

Specific proteins and their aggregates form toxic amyloid plaques and neurofibrillary tangles in the brains of people suffering from neurodegenerative diseases such as Alzheimer's and Parkinson's. It is important to study these conformational changes to identify and differentiate these diseases at an early stage so that timely medication is provided to patients. Mid-infrared spectroscopy can be used to monitor these changes by studying the line-shapes and the relative absorbances of amide bands present in proteins. This work focusses on the spectroscopy of the protein, Bovine Serum Albumin as an exemplar, and its aggregates using germanium on silicon waveguides in the 1900-1000 cm -1 (5.3-10.0 µm) spectral region.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research