Open AccessResolving tissue chromophore concentration at MRI resolution using multi-wavelength photo-magnetic imaging
Author(s) -
Maha Algarawi,
Hakan Erkol,
Alex Luk,
Seunghoon Ha,
Mehmet Ünlü,
Gültekin Gülşen,
Farouk Nouizi
Publication year - 2020
Publication title -
biomedical optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.397538
Subject(s) - chromophore , wavelength , materials science , laser , optics , image resolution , imaging phantom , magnetic resonance imaging , absorption (acoustics) , resolution (logic) , nuclear magnetic resonance , chemistry , optoelectronics , physics , computer science , medicine , organic chemistry , artificial intelligence , radiology
Photo-magnetic imaging (PMI) is an emerging optical imaging modality that showed great performance on providing absorption maps with high resolution and quantitative accuracy. As a multi-modality technology, PMI warms up the imaged object using a near infrared laser while temperature variation is measured using magnetic resonance imaging. By probing tissue at multiple wavelengths, concentration of the main tissue chromophores such as oxy- and deoxy-hemoglobin, lipid, and water are obtained then used to derive functional parameters such as total hemoglobin concentration and relative oxygen saturation. In this paper, we present a multi-wavelength PMI system that was custom-built to host five different laser wavelengths. After recovering the high-resolution absorption maps, a least-squared minimization process was used to resolve the different chromophore concentration. The performance of the system was experimentally tested on a phantom with two different dyes. Their concentrations were successfully assessed with high spatial resolution and average accuracy of nearly 80%.