Open AccessFeasibility of near-infrared spectroscopy as a tool for anatomical mapping of the human epicardium
Author(s) -
Rajinder P. SinghMoon,
Soo Young Park,
Diego M Song Cho,
Agastya Vaidya,
Charles C. Marboe,
Elaine Wan,
Christine P. Hendon
Publication year - 2020
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.394294
Subject(s) - ablation , adipose tissue , epicardial adipose tissue , medicine , biomedical engineering , ex vivo , endocardium , epicardial fat , cardiology , materials science , in vivo , biology , microbiology and biotechnology
Epicardial ablation is necessary for the treatment of ventricular tachycardias refractory to endocardial ablation due to arrhythmic substrates involving the epicardium. The human epicardium is composed of adipose tissue and coronary vasculature embedded on the surface and within the myocardium, which can complicate electroanatomical mapping, electrogram interpretation and ablation delivery. We propose using near-infrared spectroscopy (NIRS) to decipher adipose tissue from myocardial tissue within human hearts ex vivo . Histological measurement of epicardial adipose thickness direct correlated (R = 0.884) with the adipose contrast index. These results demonstrate the potential of NIRS integrated catheters for mapping the spatial distribution of epicardial substrates and could aid in improving guidance during epicardial ablation interventions.