Open AccessMultifunctional laser speckle imaging
Author(s) -
E Du,
Shuhao Shen,
Shau Poh Chong,
Nanguang Chen
Publication year - 2020
Publication title -
biomedical optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.388856
Subject(s) - speckle pattern , optics , speckle imaging , blood flow , laser , contrast (vision) , laser doppler velocimetry , materials science , physics , medicine , radiology
We have developed a multi-functional laser speckle imaging system, which can be operated in both the surface illumination laser speckle contrast imaging (SI-LSCI) mode and the line scan laser speckle contrast imaging (LS-LSCI) mode. The system has been applied to imaging the chicken embryos to visualize both the blood flow and morphological details of the vasculature. The experimental results demonstrated that LS-LSCI is capable of detecting and quantifying blood flow in blood vessels smaller and deeper than those detectable by conventional SI-LSCI. Furthermore, the line scan mode is also capable of producing depth-resolved absorption-based morphological images of tissue, augmenting flow-based functional images.