Open AccessCorneal hydration assessment indicator based on terahertz time domain spectroscopy
Author(s) -
Jiali Yao,
Jianjun Ma,
Jiehui Zhao,
Pengfei Qi,
Mengdi Li,
Lin Liu,
Lu Sun,
Xiaolei Wang,
Weiwei Liu,
Yan Wang
Publication year - 2020
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.387826
Subject(s) - terahertz radiation , terahertz time domain spectroscopy , spectroscopy , materials science , terahertz spectroscopy and technology , optics , reflection (computer programming) , analytical chemistry (journal) , chemistry , optoelectronics , physics , computer science , chromatography , quantum mechanics , programming language
Terahertz technology has shown broad prospects for measuring corneal water content, which is an important parameter of ocular health. Based on terahertz time-domain spectroscopy, a new indicator named characteristic ratio (CR) of the sum of low (0.2-0.7 THz) and high (0.7-1.0 THz) frequency spectral intensities, for characterizing corneal hydration is introduced in this work. CR is calculated from the real-time reflection spectra after error elimination of ex vivo human corneal stroma samples which is collected during dehydration under natural conditions (temperature: 22.4 ± 0.3°C; humidity: 20.0 ± 3%). The corresponding relationships between CR and corneal water content are reported. Comparing the linear fitting results with the published similar study, the coefficients of variation of the fitting slope and intercept are 39.4% and 27.6% lower, respectively. This indicates that this approach has the potential to achieve corneal water content in-vivo detection in the future.