Open AccessEstimating intracranial pressure using pulsatile cerebral blood flow measured with diffuse correlation spectroscopy
Author(s) -
Alexander Ruesch,
Jason Yang,
Samantha Schmitt,
Deepshikha Acharya,
Smith Ma,
Jana M. Kainerstorfer
Publication year - 2020
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.386612
Subject(s) - pulsatile flow , intracranial pressure , cerebral blood flow , blood flow , biomedical engineering , photoplethysmogram , pulse (music) , pulse pressure , medicine , blood pressure , cardiology , materials science , anesthesia , optics , computer science , physics , filter (signal processing) , computer vision , detector
Measuring intracranial pressure (ICP) is necessary for the treatment of severe head injury but measurement systems are highly invasive and introduce risk of infection and complications. We developed a non-invasive alternative for quantifying ICP using measurements of cerebral blood flow (CBF) by diffuse correlation spectroscopy. The recorded cardiac pulsation waveform in CBF undergoes morphological changes in response to ICP changes. We used the pulse shape to train a randomized regression forest to estimate the underlying ICP and demonstrate in five non-human primates that DCS-based estimation can explain over 90% of the variance in invasively measured ICP.