Open AccessQuantification of structural and microvascular changes for diagnosing early-stage oral cancer
Author(s) -
Ping Hsien Chen,
YuJu Chen,
Yi Fen Chen,
Yi Chen Yeh,
Kuo Wei Chang,
Ming Hou,
Wen Chuan Kuo
Publication year - 2020
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.384608
Subject(s) - optical coherence tomography , pathology , cancer , medicine , in vivo , stage (stratigraphy) , carcinogenesis , preclinical imaging , radiology , biology , paleontology , microbiology and biotechnology
Changes in mucosal microvascular networks, called intraepithelial papillary capillary loops (IPCL), are an important key factor for diagnosing early-stage oral cancer in vivo. Nevertheless, there are a lack of tools to quantify these changes objectively. This is the first study to quantify the IPCL changes in vivo to differentiate benign or malignant oral lesions by the optical coherence tomography (OCT) technique. K14-EGFP-miR-211-GFP transgenic mice were inducted by 4-Nitroquinoline-1-oxide to produce oral carcinogenesis in different stages, including normal, premalignancy and cancer. The results showed significant differentiation between benign or malignant lesions by OCT quantitative parameters, including epithelial thickness, IPCL density, radius and tortuosity.