Ultra-sensitive optical coherence elastography using a high-dynamic-range force loading scheme for cervical rigidity assessment | Zendy

Xinwen Yao | Zendy; Dawei Li | Zendy; HyeonCheol Park | Zendy; Defu Chen | Zendy; Honghua Guan | Zendy; Mala Mahendroo | Zendy; Xingde Li | Zendy

Open Access

Ultra-sensitive optical coherence elastography using a high-dynamic-range force loading scheme for cervical rigidity assessment

Author(s) -

Xinwen Yao,

Dawei Li,

HyeonCheol Park,

Defu Chen,

Honghua Guan,

Mala Mahendroo,

Xingde Li

Publication year - 2019

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.383720

Subject(s) - optical coherence tomography , optics , rigidity (electromagnetism) , elastography , dynamic range , coherence (philosophical gambling strategy) , materials science , computer science , biomedical engineering , physics , acoustics , ultrasound , medicine , composite material , quantum mechanics

An ultra-sensitive, wide-range force loading scheme is proposed for compression optical coherence elastography (OCE) that allows for the quantitative analysis of cervical tissue elasticity ex vivo . We designed a force loading apparatus featuring a water sink for minuscule incremental loading through a volume-controlled water droplet, from which the Young's modulus can be calculated by fitting the stress-strain curve. We validated the performance of the proposed OCE system on homogenous agar phantoms, showing the Young's modulus can be accurately estimated using this scheme. We then measured the Young's modulus of rodent cervical tissues acquired at different gestational ages, showing that the cervical rigidity of rodents was significantly dropped when entering the third trimester of pregnancy.

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