Open AccessRobust, accurate depth-resolved attenuation characterization in optical coherence tomography
Author(s) -
Kaiyan Li,
Wenxuan Liang,
Zihan Yang,
Yanmei Liang,
Shui Wan
Publication year - 2020
Publication title -
biomedical optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.382493
Subject(s) - optical coherence tomography , attenuation , robustness (evolution) , optics , computer science , attenuation coefficient , tomography , diffuse optical imaging , biological imaging , algorithm , biological system , physics , chemistry , biochemistry , biology , fluorescence , gene
Depth-resolved optical attenuation coefficient is a valuable tissue parameter that complements the intensity-based structural information in optical coherent tomography (OCT) imaging. Herein we systematically analyzed the under- and over-estimation bias of existing depth-resolved methods when applied to real biological tissues, and then proposed a new algorithm that remedies these issues and accommodates general OCT data that contain incomplete decay and noise floor, thereby affording consistent estimation accuracy for practical biological samples of different scattering properties. Compared with other algorithms, our method demonstrates remarkably improved estimation accuracy and numerical robustness, as validated via numerical simulations and on experimental OCT data obtained from both silicone-TiO 2 phantoms and human ventral tongue leukoplakia samples.