Open AccessIn-vivo 3D corneal elasticity using air-coupled ultrasound optical coherence elastography
Author(s) -
Zi Jin,
Reza Khazaeinezhad,
Jiang Zhu,
JinYi Yu,
Yueqiao Qu,
Youmin He,
Yan Li,
Tomás Gómez Álvarez-Arenas,
Fan Liu,
Zhongping Chen
Publication year - 2019
Publication title -
biomedical optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.10.006272
Subject(s) - cornea , optical coherence tomography , elastography , elasticity (physics) , ultrasound , ex vivo , in vivo , optics , biomedical engineering , materials science , medicine , physics , acoustics , biology , microbiology and biotechnology , composite material
Corneal elasticity can resist elastic deformations under intraocular pressure to maintain normal corneal shape, which has a great influence on corneal refractive function. Elastography can measure tissue elasticity and provide a powerful tool for clinical diagnosis. Air-coupled ultrasound optical coherence elastography (OCE) has been used in the quantification of ex-vivo corneal elasticity. However, in-vivo imaging of the cornea remains a challenge. The 3D air-coupled ultrasound OCE with an axial motion artifacts correction algorithm was developed to distinguish the in-vivo cornea vibration from the axial eye motion in anesthetized rabbits and visualize the elastic wave propagation clearly. The elastic wave group velocity of in-vivo rabbit cornea was measured to be 5.96 ± 0.55 m/s, which agrees with other studies. The results show the potential of 3D air-coupled ultrasound OCE with an axial motion artifacts correction algorithm for quantitative in-vivo assessment of corneal elasticity.