Open AccessCharacterization and modeling of acousto-optic signal strengths in highly scattering media
Author(s) -
Alexander Bengtsson,
David Hill,
Meng Li,
Mengqiao Di,
Magnus Cinthio,
Tobias Erlöv,
Stefan AnderssonEngels,
Nina Reistad,
Andreas Walther,
Lars Rippe,
Stefan Kröll
Publication year - 2019
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.10.005565
Subject(s) - signal (programming language) , optics , optical tomography , ultrasound , medical imaging , computer science , medical physics , physics , tomography , acoustics , artificial intelligence , programming language
Ultrasound optical tomography (UOT) is an imaging technique based on the acousto-optic effect that can perform optical imaging with ultrasound resolution inside turbid media, and is thus interesting for biomedical applications, e.g. for assessing tissue blood oxygenation. In this paper, we present near background free measurements of UOT signal strengths using slow light filter signal detection. We carefully analyze each part of our experimental setup and match measured signal strengths with calculations based on diffusion theory. This agreement between experiment and theory allows us to assert the deep tissue imaging potential of ∼ 5 cm for UOT of real human tissues predicted by previous theoretical studies [Biomed. Opt. Express8, 4523 (2017)] with greater confidence, and indicate that future theoretical analysis of optimized UOT systems can be expected to be reliable.