Recovery of the diffuse correlation spectroscopy data-type from speckle contrast measurements: towards low-cost, deep-tissue blood flow measurements | Zendy

Murali Krishnamoorthy | Zendy; A. K. Nandakumaran | Zendy; Turgut Durduran | Zendy; Hari M. Varma | Zendy

Open Access

Recovery of the diffuse correlation spectroscopy data-type from speckle contrast measurements: towards low-cost, deep-tissue blood flow measurements

Author(s) -

Murali Krishnamoorthy,

A. K. Nandakumaran,

Turgut Durduran,

Hari M. Varma

Publication year - 2019

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.10.005395

Subject(s) - speckle pattern , optics , speckle imaging , contrast (vision) , spectroscopy , materials science , blood flow , biomedical engineering , nuclear magnetic resonance , medicine , physics , radiology , quantum mechanics

A multi-step Volterra integral equation-based algorithm was developed to measure the electric field auto-correlation function from multi-exposure speckle contrast data. This enabled us to derive an estimate of the full diffuse correlation spectroscopy data-type from a low-cost, camera-based system. This method is equally applicable for both single and multiple scattering field auto-correlation models. The feasibility of the system and method was verified using simulation studies, tissue mimicking phantoms and subsequently in in vivo experiments.

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