Open AccessRecovery of the diffuse correlation spectroscopy data-type from speckle contrast measurements: towards low-cost, deep-tissue blood flow measurements
Author(s) -
Krishna P. Murali,
A. K. Nandakumaran,
Turgut Durdurán,
Hari M. Varma
Publication year - 2019
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.10.005395
Subject(s) - speckle pattern , optics , diffuse optical imaging , contrast (vision) , spectroscopy , measure (data warehouse) , speckle imaging , scattering , computer science , correlation , biological system , artificial intelligence , biomedical engineering , physics , mathematics , tomography , medicine , data mining , quantum mechanics , biology , geometry
A multi-step Volterra integral equation-based algorithm was developed to measure the electric field auto-correlation function from multi-exposure speckle contrast data. This enabled us to derive an estimate of the full diffuse correlation spectroscopy data-type from a low-cost, camera-based system. This method is equally applicable for both single and multiple scattering field auto-correlation models. The feasibility of the system and method was verified using simulation studies, tissue mimicking phantoms and subsequently in in vivo experiments.