Open AccessOptical properties of brain tissues at the different stages of glioma development in rats: pilot study
Author(s) -
Elina A. Genina,
Alexey N. Bashkatov,
Daria K. Tuchina,
Polina A. Dyachenko,
Nikita A. Navolokin,
Alexander Shirokov,
Alexander Khorovodov,
Andrey Terskov,
Maria Klimova,
Aysel Mamedova,
Inna Blokhina,
Ilana Agranovich,
Ekaterina Zinchenko,
Oxana Semyachkina-Glushkovskaya,
Valery V. Tuchin
Publication year - 2019
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.10.005182
Subject(s) - attenuation coefficient , collimated light , transmittance , glioma , materials science , optics , scattering , light scattering , anisotropy , scattering coefficient , biomedical engineering , absorption (acoustics) , pathology , nuclear magnetic resonance , optoelectronics , medicine , cancer research , laser , physics
In this paper, measurements of the optical properties (diffuse reflectance, total and collimated transmittance) of brain tissues in healthy rats and rats with C6-glioma were performed in the spectral range from 350 to 1800 nm. Using these measurements, characteristic tissue optical parameters, such as absorption coefficient, scattering coefficient, reduced scattering coefficient, and scattering anisotropy factor were reconstructed. It was obtained that the 10-day development of glioma led to increase of absorption coefficient, which was associated with the water content elevation in the tumor. However, further development of the tumor (formation of the necrotic core) led to decrease in the water content. The dependence of the scattering properties on the different stages of model glioma development was more complex. Light penetration depth into the healthy and tumor brain was evaluated.