Open AccessPolar organization of collagen in human cardiac tissue revealed with polarimetric second-harmonic generation microscopy
Author(s) -
Kamdin Mirsanaye,
Ahmad Golaraei,
Fayez Habach,
Edvardas Žurauskas,
Jonas Venius,
Ričardas Rotomskis,
Virginijus Barzda
Publication year - 2019
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.10.005025
Subject(s) - second harmonic generation , materials science , polarity (international relations) , polarimetry , microscopy , human heart , biomedical engineering , optical mapping , electrical conduction system of the heart , polar , optics , anatomy , biophysics , chemistry , medicine , electrocardiography , biology , cardiology , physics , scattering , laser , biochemistry , astronomy , cell
Polarimetric second-harmonic generation (P-SHG) microscopy is used to characterize the composition and polarity of collagen fibers in various regions of human cardiac tissue. The boundary between the cardiac conduction system and myocardium is shown to possess a distinct composition of collagen compared to other regions in the heart. Moreover, collagen fibers in this region are macroscopically organized in a unipolar arrangement, which may consequently aid in effective propagation of the electrical signal through the cardiac conduction system.