Visual method for evaluating liver function: targeted in vivo fluorescence imaging of the asialoglycoprotein receptor | Zendy

Xiaojing Song | Zendy; Shuyou Wang | Zendy; Chong Zhao | Zendy; Weibo Zhang | Zendy; Guangjun Wang | Zendy; Shuyong Jia | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Visual method for evaluating liver function: targeted in vivo fluorescence imaging of the asialoglycoprotein receptor

Author(s) -

Xiaojing Song,

Shuyou Wang,

Chong Zhao,

Weibo Zhang,

Guangjun Wang,

Shuyong Jia

Publication year - 2019

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.10.005015

Subject(s) - asialoglycoprotein receptor , in vivo , pathology , medicine , liver function , chemistry , biology , hepatocyte , in vitro , biochemistry , microbiology and biotechnology

The visual evaluation of liver function (LF) has always been a hot topic in research on liver diseases. In vivo fluorescence imaging (IVFI) of the Cy5.5-galactosylated polylysine (Cy5.5-GP) probe targeting asialoglycoprotein receptor (ASGPR), for evaluating LF in chronic alcoholic liver injury (cALI) mice was investigated in this study. The decrease of fluorescence signals in the livers showed a biological relationship with the liver ASGPR expression, histology, and serum marker levels of LF in cALI mice. The targeted IVFI of ASGPR as a novel method can intuitively and noninvasively display the characteristics of liver's ASGPR level to provide a reference for evaluating LF.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research