Open AccessVisual method for evaluating liver function: targeted in vivo fluorescence imaging of the asialoglycoprotein receptor
Author(s) -
Xiaojing Song,
Shuyou Wang,
Chong Zhao,
Weibo Zhang,
Guangjun Wang,
Shuyong Jia
Publication year - 2019
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.10.005015
Subject(s) - asialoglycoprotein receptor , in vivo , pathology , liver function , medicine , chemistry , biology , hepatocyte , in vitro , biochemistry , microbiology and biotechnology
The visual evaluation of liver function (LF) has always been a hot topic in research on liver diseases. In vivo fluorescence imaging (IVFI) of the Cy5.5-galactosylated polylysine (Cy5.5-GP) probe targeting asialoglycoprotein receptor (ASGPR), for evaluating LF in chronic alcoholic liver injury (cALI) mice was investigated in this study. The decrease of fluorescence signals in the livers showed a biological relationship with the liver ASGPR expression, histology, and serum marker levels of LF in cALI mice. The targeted IVFI of ASGPR as a novel method can intuitively and noninvasively display the characteristics of liver's ASGPR level to provide a reference for evaluating LF.