Open AccessDevelopment of a stand-alone DCS system for monitoring absolute cerebral blood flow
Author(s) -
Mahro Khalid,
Daniel Milej,
Ajay Rajaram,
Androu Abdalmalak,
Laura Morrison,
Mamadou Diop,
Keith St. Lawrence
Publication year - 2019
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.10.004607
Subject(s) - diffuse optical imaging , cerebral blood flow , blood flow , biomedical engineering , computer science , measure (data warehouse) , optical imaging , near infrared spectroscopy , biological system , optics , materials science , medicine , physics , artificial intelligence , cardiology , iterative reconstruction , database , biology
Diffuse correlation spectroscopy (DCS) is a noninvasive optical technique for monitoring cerebral blood flow (CBF). This work presents a stand-alone DCS system capable of monitoring absolute CBF by incorporating a quantitative dynamic contrast-enhanced (DCE) technique. Multi-distance data were acquired to measure the tissue optical properties and to perform DCE experiments. Feasibility of the technique was assessed in piglets in which the optical properties were measured independently by time-resolved near-infrared spectroscopy. A strong linear correlation was observed between CBF values derived using the two sets of optical properties, demonstrating that this hybrid DCS approach can provide real-time monitoring of absolute CBF.