Development of a stand-alone DCS system for monitoring absolute cerebral blood flow | Zendy

Mahro Khalid | Zendy; Daniel Milej | Zendy; Ajay Rajaram | Zendy; Androu Abdalmalak | Zendy; Laura Morrison | Zendy; Mamadou Diop | Zendy; Keith St. Lawrence | Zendy

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Development of a stand-alone DCS system for monitoring absolute cerebral blood flow

Author(s) -

Mahro Khalid,

Daniel Milej,

Ajay Rajaram,

Androu Abdalmalak,

Laura Morrison,

Mamadou Diop,

Keith St. Lawrence

Publication year - 2019

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.10.004607

Subject(s) - diffuse optical imaging , cerebral blood flow , blood flow , biomedical engineering , measure (data warehouse) , spectroscopy , computer science , optical imaging , near infrared spectroscopy , optics , materials science , biological system , medicine , physics , artificial intelligence , cardiology , iterative reconstruction , database , biology , quantum mechanics

Diffuse correlation spectroscopy (DCS) is a noninvasive optical technique for monitoring cerebral blood flow (CBF). This work presents a stand-alone DCS system capable of monitoring absolute CBF by incorporating a quantitative dynamic contrast-enhanced (DCE) technique. Multi-distance data were acquired to measure the tissue optical properties and to perform DCE experiments. Feasibility of the technique was assessed in piglets in which the optical properties were measured independently by time-resolved near-infrared spectroscopy. A strong linear correlation was observed between CBF values derived using the two sets of optical properties, demonstrating that this hybrid DCS approach can provide real-time monitoring of absolute CBF.

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