Review of micro-optical sectioning tomography (MOST): technology and applications for whole-brain optical imaging [Invited] | Zendy

Ting Zheng | Zendy; Zhao Feng | Zendy; Xiaojun Wang | Zendy; Tao Jiang | Zendy; Rui Jin | Zendy; Peilin Zhao | Zendy; Ting Luo | Zendy; Hui Gong | Zendy; Qingming Luo | Zendy; Jing Yuan | Zendy

Open Access

Review of micro-optical sectioning tomography (MOST): technology and applications for whole-brain optical imaging [Invited]

Author(s) -

Ting Zheng,

Zhao Feng,

Xiaojun Wang,

Tao Jiang,

Rui Jin,

Peilin Zhao,

Ting Luo,

Hui Gong,

Qingming Luo,

Jing Yuan

Publication year - 2019

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.10.004075

Subject(s) - mesoscopic physics , neuroimaging , optical imaging , computer science , neuroscience , optical tomography , optical sectioning , nanotechnology , artificial intelligence , microscopy , materials science , optics , iterative reconstruction , physics , biology , quantum mechanics

Elucidating connectivity and functionality at the whole-brain level is one of the most challenging research goals in neuroscience. Various whole-brain optical imaging technologies with submicron lateral resolution have been developed to reveal the fine structures of brain-wide neural and vascular networks at the mesoscopic level. Among them, micro-optical sectioning tomography (MOST) is attracting increasing attention, as a variety of technological variations and solutions tailored toward different biological applications have been optimized. Here, we summarize the recent development of MOST technology in whole-brain imaging and anticipate future improvements.

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