Open AccessReview of micro-optical sectioning tomography (MOST): technology and applications for whole-brain optical imaging [Invited]
Author(s) -
Ting Zheng,
Zuren Feng,
Xiaojun Wang,
Tao Jiang,
RuiBo Jin,
Peilin Zhao,
Ting Luo,
Hui Gong,
Qi Luo,
Jing Yuan
Publication year - 2019
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.10.004075
Subject(s) - mesoscopic physics , neuroimaging , optical imaging , optical sectioning , computer science , neuroscience , optical tomography , nanotechnology , artificial intelligence , materials science , optics , microscopy , iterative reconstruction , psychology , physics , quantum mechanics
Elucidating connectivity and functionality at the whole-brain level is one of the most challenging research goals in neuroscience. Various whole-brain optical imaging technologies with submicron lateral resolution have been developed to reveal the fine structures of brain-wide neural and vascular networks at the mesoscopic level. Among them, micro-optical sectioning tomography (MOST) is attracting increasing attention, as a variety of technological variations and solutions tailored toward different biological applications have been optimized. Here, we summarize the recent development of MOST technology in whole-brain imaging and anticipate future improvements.