Open AccessQuantitative measurements of cerebral blood flow with near-infrared spectroscopy
Author(s) -
Thao Pham,
Kristen Tgavalekos,
Angelo Sassaroli,
Giles Blaney,
Sergio Fantini
Publication year - 2019
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.10.002117
Subject(s) - cerebral blood flow , near infrared spectroscopy , blood flow , hemodynamics , spectroscopy , functional near infrared spectroscopy , nuclear magnetic resonance , biomedical engineering , medicine , nuclear medicine , prefrontal cortex , anesthesia , cardiology , optics , physics , cognition , quantum mechanics , psychiatry
We propose a new near-infrared spectroscopy (NIRS) method for quantitative measurements of cerebral blood flow (CBF). Because this method uses concepts of coherent hemodynamics spectroscopy (CHS), we identify this new method with the acronym NIRS-CHS. We tested this method on the prefrontal cortex of six healthy human subjects during mean arterial pressure (MAP) transients induced by the rapid deflation of pneumatic thigh cuffs. A comparison of CBF dynamics measured with NIRS-CHS and with diffuse correlation spectroscopy (DCS) showed a good agreement for characteristic times of the CBF transient. We also report absolute measurements of baseline CBF with NIRS-CHS (69 ± 6 ml/100g/min over the six subjects). NIRS-CHS can provide more accurate measurements of CBF with respect to previously reported NIRS surrogates of CBF.