Quantitative measurements of cerebral blood flow with near-infrared spectroscopy | Zendy

Thao Pham | Zendy; Kristen Tgavalekos | Zendy; Angelo Sassaroli | Zendy; Giles Blaney | Zendy; Sergio Fantini | Zendy

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Quantitative measurements of cerebral blood flow with near-infrared spectroscopy

Author(s) -

Thao Pham,

Kristen Tgavalekos,

Angelo Sassaroli,

Giles Blaney,

Sergio Fantini

Publication year - 2019

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.10.002117

Subject(s) - cerebral blood flow , spectroscopy , blood flow , infrared , infrared spectroscopy , optics , near infrared spectroscopy , materials science , functional near infrared spectroscopy , medicine , chemistry , neuroscience , physics , psychology , cognition , quantum mechanics , prefrontal cortex , organic chemistry

We propose a new near-infrared spectroscopy (NIRS) method for quantitative measurements of cerebral blood flow (CBF). Because this method uses concepts of coherent hemodynamics spectroscopy (CHS), we identify this new method with the acronym NIRS-CHS. We tested this method on the prefrontal cortex of six healthy human subjects during mean arterial pressure (MAP) transients induced by the rapid deflation of pneumatic thigh cuffs. A comparison of CBF dynamics measured with NIRS-CHS and with diffuse correlation spectroscopy (DCS) showed a good agreement for characteristic times of the CBF transient. We also report absolute measurements of baseline CBF with NIRS-CHS (69 ± 6 ml/100g/min over the six subjects). NIRS-CHS can provide more accurate measurements of CBF with respect to previously reported NIRS surrogates of CBF.

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