Open AccessSolid phantom recipe for diffuse optics in biophotonics applications: a step towards anatomically correct 3D tissue phantoms
Author(s) -
Sanathana Konugolu Venkata Sekar,
Andréa Pacheco,
Pierluigi Martella,
Haiyang Li,
Pranav Lanka,
Antonio Pifferi,
Stefan AnderssonEngels
Publication year - 2019
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.10.002090
Subject(s) - imaging phantom , biophotonics , materials science , optics , biomedical engineering , diffuse optical imaging , optoelectronics , physics , tomography , medicine , photonics
We present a tissue mimicking optical phantom recipe to create robust well tested solid phantoms. The recipe consists of black silicone pigment (absorber), silica microspheres (scatterer) and silicone rubber (SiliGlass, bulk material). The phantom recipe was characterized over a broadband spectrum (600-1100 nm) for a wide range of optical properties (absorption 0.1-1 cm -1 , reduced scattering 5-25 cm -1 ) that are relevant to human organs. The results of linearity show a proper scaling of optical properties as well as the absence of coupling between the absorber and scatterer at different concentrations. A reproducibility of 4% among different preparations was obtained, with a similar grade of spatial homogeneity. Finally, a 3D non-scattering mock-up phantom of an infant torso made with the same recipe bulk material (SiliGlass) was presented to project the futuristic aspect of our work that is 3D printing human organs of biomedical relevance.