Open AccessDevelopment of a reproducible in vivo laser-induced scar model for wound healing study and management
Author(s) -
Myeongjin Kim,
Sung Won Kim,
Hye-Jin Kim,
Chi Woo Hwang,
Jong Man Choi,
Hyun Wook Kang
Publication year - 2019
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.10.001965
Subject(s) - wound healing , medicine , buttocks , animal model , in vivo , surgery , scars , rat model , biomedical engineering , pathology , biology , microbiology and biotechnology
The aim of the current study was to establish animal scar models in a simple and rapid manner by comparing three methods. Wounds were created on the buttocks of Sprague Dawley rats. For Group 1, the initial wound was created by surgical incision. For Groups 2 and 3, a 1470-nm laser was employed to generate dermal burns as the initial wound. The wounds in Groups 1 and 3 were then sutured for three days. After the wound healing, Group 2 generated the largest collagen proportion with abundant collagen type I and significant increases in α-SMA and TGF-β1. The proposed method can be an efficient way to develop rat scar models in a simple manner for evaluating scar treatment.