Open AccessModeling of the hemodynamics in the feet of patients with peripheral artery disease
Author(s) -
Alessandro Marone,
Jennifer W. Hoi,
Michael A. Khalil,
H. K. Kim,
Gautam Shrikhande,
Rajeev Dayal,
Danielle Bajakian,
Andreas H. Hielscher
Publication year - 2019
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.10.000657
Subject(s) - hemodynamics , peripheral , cuff , circulatory system , medicine , thigh , cardiology , occlusion , arterial disease , vascular disease , radiology , surgery
To simulate the hemodynamic effects in the feet in response to a thigh cuff occlusion, we have developed a multi-compartmental model in which the circulatory system for the leg is represented by its electrical equivalents. Dynamic vascular optical tomographic imaging data previously obtained from 20 patients with peripheral artery disease (PAD) and 20 healthy subjects is used to test the model. Analyzing the clinical data with the support of the model yields diagnostic specificity and sensitivity in the 90-95% range, significantly higher than previously reported.