Open AccessIn vivo measurement of the human crystalline lens equivalent refractive index using extended-depth OCT
Author(s) -
Yeon S. Chang,
Gabrielle Monterano Mesquita,
Siobhan Williams,
Giovanni Gregori,
Florence Cabot,
Arthur Ho,
Marco Ruggeri,
Sonia H. Yoo,
Jean Marie Parel,
Fabrice Manns
Publication year - 2019
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.10.000411
Subject(s) - optics , refractive index , lens (geology) , human eye , refraction , materials science , in vivo , intraocular lens , optical power , biomedical engineering , physics , medicine , laser , microbiology and biotechnology , biology
The lens equivalent refractive index (RI) is commonly used in calculations of crystalline lens power. However, accurate determination of the equivalent RI in vivo is challenging due to the need of multiple measurements with different ocular biometry devices. A custom extended-depth Spectral Domain-OCT system was utilized to provide measurements of corneal and lens surface curvatures and all intraocular distances required for determination of the lens equivalent RI. Ocular biometry and refraction were input into a computational model eye from which the equivalent RI was calculated. Results derived from human subjects of a wide age range show a decrease in RI with age and demonstrate the capability of in vivo measurements of the equivalent RI with extended-depth OCT.