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Reduced Levels of MMP‐2 and TIMP‐1 in Dyssegmental Dysplasia
Author(s) -
Uchide Kiyoshi,
Ueno Hirohisa,
Takizawa Noboru,
Okada Yasunori
Publication year - 2003
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1359/jbmr.2003.18.2.381
Subject(s) - matrix metalloproteinase , medicine , dysplasia , gestation , etiology , ossification , pathology , anatomy , biology , pregnancy , genetics
Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) were measured in a mild case of dyssegmental dysplasia. X‐ray pictures of a female baby born vaginally at 39 weeks of gestation showed short, bent, dumbbell‐shaped long bones of the limbs and profound dyssegmental ossification in the spine, findings characteristic of dyssegmental dysplasia. When the levels of MMP‐1, MMP‐2, MMP‐9, TIMP‐1, and TIMP‐2 were measured, the levels of MMP‐2 and TIMP‐1 were significantly reduced. This case might provide a clue to disclose the etiology of dyssegmental dysplasia.