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Transforming Growth Factor‐β1 Negatively Regulates Crystallin Expression in Teeth
Author(s) -
Thyagarajan Tamizchelvi,
Kulkarni Ashok B.
Publication year - 2002
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1359/jbmr.2002.17.9.1710
Subject(s) - phenotype , genetically modified mouse , transgene , transforming growth factor , biology , crystallin , transforming growth factor beta , microbiology and biotechnology , growth differentiation factor , genetics , gene , bone morphogenetic protein
Previously, we have reported that targeted overexpression of transforming growth factor (TGF) β1 in the teeth of the transgenic mice ( d TGF‐β1) results in a novel tooth phenotype phenomimicking the most prevalent tooth disorders in human. This phenotype was associated with discoloration and attrition of teeth due to defective mineralization. Here, we report a novel expression of crystallin family members in developing mouse teeth and its regulation by TGF‐β1 in these transgenic mice. αB‐ and β‐crystallins were found to be elevated in d TGF‐β1 mouse teeth, whereas γ‐crystallin (γB, γC, and γF), a marker of cell differentiation, was significantly reduced. Because crystallins are believed to be stress‐related proteins, their expression in teeth implicates them in a similar role because teeth are constantly subjected to physical friction and temperature fluctuations.