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Tumors Associated With Oncogenic Osteomalacia Express Genes Important in Bone and Mineral Metabolism
Author(s) -
De Beur Suzanne M. Jan,
Finnegan Richard B.,
Vassiliadis John,
Cook Brian,
Barberio Dana,
Estes Scott,
Manavalan Partha,
Petroziello Joseph,
Madden Stephen L.,
Cho Justin Y.,
Kumar Rajiv,
Levine Michael A.,
Schiavi Susan C.
Publication year - 2002
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1359/jbmr.2002.17.6.1102
Subject(s) - osteomalacia , calcitriol , gene , biology , gene expression , bone mineral , pathology , cancer research , medicine , endocrinology , vitamin d and neurology , genetics , osteoporosis
Oncogenic osteomalacia (OOM) is associated with primitive mesenchymal tumors that secrete phosphaturic factors resulting in low serum concentrations of phosphate and calcitriol, phosphaturia, and defective bone mineralization. To identify overexpressed genes in these tumors, we compared gene expression profiles of tumors resected from patients with OOM and histologically similar control tumors using serial analysis of gene expression (SAGE). Three hundred and sixty‐four genes were expressed at least twofold greater in OOM tumors compared with control tumors. A subset of 67 highly expressed genes underwent validation with an extended set of OOM and control tumors using array analysis or reverse‐transcription polymerase chain reaction (RT‐PCR). Ten of these validated genes were consistently overexpressed in all OOM tumors relative to control tumors. Strikingly, genes with roles in bone matrix formation, mineral ion transport, and bone mineralization were highly expressed in the OOM tumors.