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Blood Flow Measurements with [ 15 O]H 2 O and [ 18 F]Fluoride Ion PET in Porcine Vertebrae
Author(s) -
Piert Morand,
Zittel Tilman T.,
Machulla HansJurgen,
Becker Georg Alexander,
Jahn Michael,
Maier Gerhard,
Bares Roland,
Becker Horst Dieter
Publication year - 1998
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1359/jbmr.1998.13.8.1328
Subject(s) - fluoride , blood flow , chemistry , ion , positron emission tomography , analytical chemistry (journal) , nuclear medicine , radiochemistry , chromatography , medicine , inorganic chemistry , organic chemistry
A dual positron emission tomography (PET) tracer study with [ 18 F]fluoride and the freely diffusible tracer [ 15 O]H 2 O was performed to measure the capillary transport of [ 18 F]fluoride and to evaluate the potential of [ 18 F]fluoride ion PET to quantitate bone blood flow. Under the condition of a high predictable single‐pass extraction fraction (E F ) for [ 18 F]fluoride, the [ 18 F]fluoride ion influx transport constant (K 1F ), derived from kinetic [ 18 F]fluoride ion PET measurements, can be used to estimate bone blood flow. Bone blood flow was measured in vertebral bodies by dynamic [ 15 O]H 2 O PET during continuous ventilation with N 2 O, O 2 , and Isoflurane (FiO 2 = 0.3) in seven adult mini pigs, followed by dynamic [ 18 F]fluoride ion PET. The mean blood flow measured by [ 15 O]H 2 O (Flow H 2O ) was 0.145 ± 0.047 ml·minute –1 ·ml –1 and the mean K 1F was 0.118 ± 0.031 ml·minute –1 ·ml –1 , respectively (mean ± SD). Regional analysis showed excellent agreement between Flow H 2O and K 1F at low flow and a significant underestimation of flow by K 1F relative to Flow H 2O in regions of normal and elevated flow. The observed relationship between parameters followed the Renkin‐Crone distribution. The permeability‐surface product was determined as 0.25 minute −1 for vertebral bodies consisting of a mixture of trabecular and cortical bone. We conclude that [ 18 F]fluoride ion PET can be used to estimate bone blood flow in low and normal flow regions, as long as the flow dependency of the E F is taken into consideration. Above blood flow values of 0.2 to 0.35 ml·minute –1 ·ml –1 , the magnitude of K 1F is increasingly independent on blood flow because diffusion limits tracer transport.