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Lack of Correlation Between Start Codon Polymorphism of the Vitamin D Receptor Gene and Bone Mineral Density in Premenopausal French Women: The OFELY Study
Author(s) -
Eccleshall T. Ross,
Garnero Patrick,
Gross Coleman,
Delmas Pierre D.,
Feldman David
Publication year - 1998
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1359/jbmr.1998.13.1.31
Subject(s) - foki , calcitriol receptor , endocrinology , medicine , genotype , bone mineral , vitamin d and neurology , osteoporosis , gene polymorphism , bone density , parathyroid hormone , bone remodeling , polymorphism (computer science) , biology , genetics , calcium , gene
Previous studies have demonstrated an association between bone mineral density (BMD) and a start codon polymorphism (SCP) of the vitamin D receptor (VDR) gene in pre‐ and postmenopausal Caucasian and Japanese women. The SCP can be determined by a restriction fragment length polymorphism defined by the Fok I restriction endonuclease. VDR alleles containing the Fok I site are denoted by f and alleles lacking the site by F. In this study, the association between BMD and the SCP was examined in a group of 174 premenopausal French women who previously had been studied for a relationship between BMD and the VDR Bsm I polymorphism. The SCP genotypes of the French women were FF 40%, Ff 44%, and ff 16% and they were independent of the Bsm I genotype. BMD was measured by dual‐energy X‐ray absorptiometry at the lumbar spine, proximal femur, forearm, and total body. In contrast to previous reports, there was no association of BMD with SCP genotype in this group of Caucasian women at any site. We also measured several biochemical indices of calcium homeostasis and bone turnover. We found no statistically significant associations between SCP genotype and calcium, parathyroid hormone, or vitamin D levels. There was a 33.5% higher level of the skeletal resorption marker N‐telopeptides of type I collagen in the women with the ff genotype when compared with women with the FF genotype ( p = 0.004). Other bone turnover markers failed to show an association with SCP genotype. In summary, the SCP genotype may not be associated with reduced BMD in all geographical or ethnic populations.