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Correlates of Trabecular and Cortical Volumetric BMD in Men of African Ancestry
Author(s) -
Sheu Yahtyng,
Cauley Jane A,
Bunker Clareann H,
Wheeler Victor W,
Patrick Alan L,
Gordon Christopher L,
Kammerer Candace M,
Zmuda Joseph M
Publication year - 2009
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1359/jbmr.090522
Subject(s) - anthropometry , tibia , medicine , cortical bone , osteoporosis , bone density , cohort , bone mineral , quantitative computed tomography , prostate cancer , endocrinology , cancer , anatomy
QCT provides a measure of volumetric BMD (vBMD) and distinguishes trabecular from cortical bone. Few studies have determined the factors related to vBMD in men, especially among men of African heritage. This study evaluated the relationship of anthropometric, medical, and behavioral factors and vBMD in a population‐based cohort of men of African ancestry ( n = 1901) ≥40 yr of age who had undergone screening for prostate cancer for the first time. Trabecular and cortical vBMD were measured at the radius and tibia by pQCT. Multiple linear regression analysis identified age, height, body weight, cigarette smoking, history of diabetes, fracture, and prostate cancer as the independent correlates of vBMD. However, associations with several variables differed between cortical and trabecular vBMD and between the radius and tibia. Longitudinal studies are needed to gain a better understanding of the mechanisms underlying these differential associations that may show new insight into the etiology of trabecular and cortical bone loss in men.